(ordered by popularity)
major
serious
difficult
real
main
particular
second
general
important
common
basic
only
whole
fundamental
central
big
specific
complex
potential
biggest
significant
similar
practical
immediate
medical
greatest
interesting
moral
technical
related
critical
linear
clinical
key
severe
underlying
chief
body
unsolved
mathematical
complicated
crucial
psychological
following
environmental
philosophical
acute
obvious
dimensional
minor
urgent
theoretical
ethical
insoluble
chronic
above
perennial
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